Antigen-presenting function of human peritoneum mesothelial cells

Origin, maturation and antigen presenting function of dendritic cells.

Dendritic cells are cells specialized for antigen capture, migration and T cell stimulation. Recent advances have been made in understanding their origin, their heterogeneity, the mechanism of antigen uptake, and the signals that induce their migration and maturation into immunostimulatory antigen-presenting cells. Dendritic cells represent the natural adjuvants for T cell responses and their t...

Ultrastructural demonstration of antigen presenting cells in human uterine tube

Langerhans cells (LCs) are the predominant antigen-presenting cells distributed in the mucosa of various organs with high antigenic exposure. They capture antigens, process and present them to the T lymphocytes. LCs are known to be present in the human female reproductive tract. Very few studies have demonstrated the presence of LCs in human uterine tubes. The aim of the present study was to de...

Distinctive localization of antigen-presenting cells in human lymph nodes.

Professional antigen-presenting cells (APCs) are sentinel cells of the immune system that present antigen to T lymphocytes and mediate an appropriate immune response. It is therefore surprising that knowledge of the professional APCs in human lymph nodes is limited. Using 3-color immunohistochemistry, we have identified APCs in human lymph nodes, excluding plasmacytoid APCs, that fall into 2 no...

The Immunomodulatory Effect of Cyclophosphamide on Regulation of T-Cell Subsets and Antigen Presenting Cells.

Endocytosis by antigen presenting cells: dendritic cells are as endocytically active as other antigen presenting cells.

Although dendritic cells are the most potent of all antigen presenting cells, they have paradoxically been regarded as having only a minimal capacity for endocytosis, which is a crucial step in antigen processing prior to presentation. Previous studies of dendritic cells, which are only available in small numbers, have been restricted to measurement of long-term endocytosis and so have stressed...